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The Truth Behind the “Salmon Sperm Facial” (And What Rejuran Actually Is)

The Truth Behind the “Salmon Sperm Facial” (And What Rejuran Actually Is)

Rejuran-Salmon Sperm Facial

You’ve probably seen the headlines: Kim Kardashian and Jennifer Aniston swear by a facial treatment made from salmon sperm. Sounds bizarre, right? But before you dismiss it as another celebrity beauty gimmick, there’s real science behind what’s known as the salmon sperm facial. The treatment is actually called Rejuran, and it had been transforming skin in South Korea for nearly a decade before arriving in Australia in 2024.

So what is a salmon sperm facial, really? It’s not a topical face mask with fishy ingredients smeared on your face. It’s an injectable treatment using purified DNA fragments from wild salmon that work at a cellular level to repair damaged skin, boost collagen production, and give you that glassy, plump skin everyone’s after.

Let’s unpack the science, separate fact from marketing hype, and help you decide if this treatment is worth the investment.

Key Insights

  • The salmon sperm facial meaning: Injectable treatment using polynucleotides (PDRN) derived from wild salmon DNA (not actual sperm on your face).
  • What it does: Stimulates collagen production, repairs damaged skin cells, improves hydration and elasticity.
  • Cost in Australia: $600-$1,350 per session, depending on treatment area.
  • Results timeline: Visible improvements within 2-4 weeks, full benefits at 4-6 weeks.
  • Best for: Fine lines, acne scarring, uneven skin tone, dark circles, dull or dehydrated skin.

What Is a Salmon Sperm Facial?

Despite the cringeworthy name, what the media are calling “salmon sperm facials” are actually a treatment called polynucleotides.

The treatment uses polydeoxyribonucleotides (PDRN for short) – purified DNA fragments extracted from the sperm of wild salmon or trout. The DNA is extracted and used to manufacture the polynucleotides, which are then formulated into an injectable gel.

Why salmon? The structural similarity between human and salmon DNA enables better absorption and utilisation by human cells. Salmon DNA is particularly rich in nucleic acids and biocompatible with human skin, meaning your body recognises and accepts it without major adverse reactions.

The most well-known brand offering this treatment is Rejuran, developed in South Korea and used for almost a decade, but was only TGA approved for use in Australia in 2024.

Think of it like this: If dermal filler adds volume by physically plumping skin, Rejuran tells your skin cells to repair themselves from the inside out. It’s regenerative rather than cosmetic camouflage.

Rejuran Facial Treatment

The Science Behind Rejuran: How Salmon DNA Repairs Your Skin

Polynucleotides aren’t new to medicine. PDRN has been investigated for tissue regeneration, wound healing, and aesthetic rejuvenation for years, particularly in South Korea, where skincare innovation leads the global market.

When injected into your skin, these DNA fragments get to work in three key ways:

1. Activating Your Skin’s Repair System 

PDRN works via adenosine A₂A receptor activation, angiogenesis, fibroblast proliferation and extracellular matrix remodelling. Translation? It activates your skin’s natural healing mechanisms and prompts dormant fibroblast cells to produce collagen and elastin again.

2. Boosting Collagen Production

The polynucleotides in Rejuran provide the building blocks that boost collagen and elastin production in the skin. Your skin becomes firmer, more elastic, and better able to hold moisture.

3. Reducing Inflammation 

PN has wound healing and anti-inflammatory properties, which makes it particularly effective for treating acne scarring, rosacea, and skin that’s damaged from sun exposure or ageing. The beauty of this approach is that you’re not temporarily masking problems, you’re supporting your skin’s ability to regenerate itself.

The-Science Behind Rejuran Infographic

What to Expect: Results and Timeline

The results from a salmon sperm facial aren’t instant like Botox or filler. This is a regenerative treatment, so you’re waiting for your skin cells to regenerate.

  • Week 1-2: You might notice your skin looks slightly more hydrated and glowy as the swelling subsides.
  • Week 2-4: You can often start to notice tangible results, like improved skin texture, smaller pores, and reduced dullness. 
  • Week 4-6: Collagen production really kicks in – fine lines soften, scarring improves, and your skin has that plump, healthy appearance.

Typically, the results of a salmon sperm facial last for around six months, but some patients report effects lasting up to a year.

For optimal results, a course of three treatments is recommended, with sessions spaced 2-4 weeks apart. After the initial treatment, a maintenance session every 6-12 months will help preserve skin health and rejuvenation.

Is It Safe? Side Effects to Know

The good news? With over 10 million syringes sold globally, no significant adverse events have been reported.

Common Side Effects (usually resolve within 1-2 days):

  • Temporary redness, swelling, bruising or mild irritation
  • Raised bumps at injection sites
  • Minor bleeding or pinprick marks
  • Temporary tightness or tenderness

Who Should Be Cautious 

Be cautious if you have fish allergies or chronic inflammatory skin conditions such as rosacea or eczema. While the DNA is highly purified and fish allergies shouldn’t be an issue, it’s worth discussing with your practitioner if you have concerns.

Pregnant or breastfeeding women should avoid the treatment due to limited safety data.

Important Regulatory Note 

Injectable PDRN is TGA-approved in Australia. This means clinics here can legally offer Rejuran treatments with proper medical oversight. Given the current state of research and the potential risks, it’s advisable to only receive treatment from qualified medical professionals using genuine, TGA-approved products.

Cost and Availability in Australia

Rejuran isn’t a budget-friendly treatment. Here’s what you can expect to pay in Australia:

In Australia, the average cost is $700-$900 per session, but this varies depending on:

  • The treatment area (full face vs under-eyes only)
  • How many vials you need
  • Your practitioner’s experience level
  • Your location (city clinics typically charge more)

For a full course of three treatments, you’re looking at $2,000-$3,000. Add annual maintenance, and it’s a significant investment.

Rejuran Facial Treatment Cost Infographic

Should You Try a Salmon Sperm Facial?

This treatment isn’t for everyone, but it might be right for you if you’re dealing with:

  • Fine lines and loss of elasticity
  • Acne scarring or uneven texture
  • Dull, dehydrated skin that won’t respond to topicals
  • Dark circles or hollowing under the eyes
  • Sun damage or photoageing
  • Rosacea or chronic inflammation

It’s particularly appealing if you want skin improvements without the frozen look of Botox or the volume of filler. You’re essentially giving your skin the tools to repair itself. Your suitability, risks and side effects can be discussed further in your consultation. You also can check our our comparison guide for different modern skin boosters to see which one is suitable for you.

Ready to Explore Regenerative Skin Treatments?

The salmon sperm facial might sound like marketing madness, but the science behind Rejuran is solid. It’s not a miracle cure that’ll reverse 20 years of sun damage overnight, but it is a genuinely innovative approach to skin rejuvenation that works with your body’s natural healing processes.

At Dr Fresh, our experienced cosmetic stay at the forefront of advanced Rejuran salmon sperm facial in melbourne that deliver real, lasting results. While Rejuran is making waves in the aesthetics industry, we offer a comprehensive range of treatments tailored to your unique skin concerns – from skin boosters and bio-remodellers to targeted solutions for acne scarring, pigmentation, and anti-ageing.

Book a consultation with our team to discuss whether regenerative treatments like polynucleotides are right for your skin goals.

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First Time Getting Lip Filler? Here’s What to Expect

First Time Getting Lip Filler? Here’s What to Expect

lip filter guide

Thinking about lip fillers but not sure where to start? You’re in the right place. Lip enhancement has become one of the most requested cosmetic treatments in Australia, with thousands of Aussies booking their first appointment every year. But between social media transformations and conflicting advice online, it’s hard to know what’s actually true about the process.

If you’re considering lip fillers for the first time, understanding how lip fillers work and what really happens during your appointment can help you feel confident and prepared. Here’s everything you need to know before you book that consultation.

Key Insights

  • Lip fillers use hyaluronic acid (a natural substance in your body) to add volume, shape, and hydration to your lips.
  • The consultation is where you’ll discuss your goals, health history, and see if you’re a suitable candidate.
  • The procedure takes approximately 1 hour, with 30 minutes of time to numb the lips and 15-30 minutes with very minimal discomfort.
  • Expect 2-7 days of swelling and bruising; final results settle within 2 weeks.
  • Results last 6-12 months on average, depending on your metabolism and the filler used.

What Are Lip Fillers and How Do They Work?

Lip fillers are injectable treatments that enhance the size, shape, and definition of your lips. Most lip fillers available in Australia contain hyaluronic acid (HA), a naturally occurring sugar molecule found in the skin, joints, and eyes. You might recognise HA from skincare products, where it’s prized for its ability to attract and hold moisture.

Lip filter treatment

Here’s how lip fillers work: hyaluronic acid can hold up to 1,000 times its weight in water. When injected into your lips, the HA gel bonds with water molecules in your tissue, creating volume and structure. Think of it as a cushion that plumps your lips from within, while also providing deep hydration that smooths fine lines around your mouth.

The HA used in dermal filler products is cross-linked, which means it’s been specially processed to give it structure and longevity.

This cross-linking allows the filler to maintain its shape for months rather than dissolving immediately. Your body gradually breaks down the hyaluronic acid over time (typically 6-12 months), which is why lip fillers are considered temporary and require maintenance treatments to maintain your results.

The Lip Filler Procedure Explained: Step by Step

Your first consultation is arguably the most important part of getting lip fillers. This is where you’ll meet your injector, discuss your aesthetic goals, and determine if you’re a suitable candidate. Here’s what typically happens during a lip filler consultation guide session.

Medical History Review 

Your injector will ask about your health history, including any allergies, medications you’re taking (especially blood thinners), previous cosmetic treatments, and whether you’ve had cold sores. Be honest, certain conditions may affect your treatment or require special precautions.

Goal Setting and Facial Analysis

This is where you explain what you want to achieve. Do you want fuller lips overall? More definition in your cupid’s bow? Better symmetry? Your injector will examine your natural lip shape, facial proportions, and bone structure to recommend a treatment plan that suits your features.

Bring reference photos if you’d like, but keep your expectations realistic. Your lips won’t (and shouldn’t) look identical to someone else’s. A skilled injector aims to enhance your natural features, not replicate someone else’s entirely different facial structure.

Questions to Ask 

This beginner’s guide to lip fillers wouldn’t be complete without emphasising the importance of asking questions during your consultation:

  • What type of filler do you recommend for my goals, and why?
  • How many millilitres do you suggest starting with?
  • What are the risks and potential complications?
  • What’s your experience level with lip injections specifically?
  • Can I see before and after examples of your work? (Note: Due to Australian TGA regulations, clinics may have limitations on displaying these publicly)
  • What happens if I’m unhappy with the results?
  • When should I consider dissolving my lip filler if needed?

Pre-Treatment Instructions

If you decide to go ahead, you’ll receive preparation instructions. Typically, you’ll need to avoid blood-thinning medications and supplements (like aspirin, ibuprofen, fish oil, and vitamin E) for 24-48 hours before your appointment to minimise bruising. You should also avoid alcohol for 24 hours beforehand and reschedule if you have an active cold sore or oral infection.

The Lip Filler Procedure Explained: Step by Step

Understanding the lip filler procedure explained in detail can ease first-time nerves. Here’s what actually happens during your appointment.

  • Step 1: Photos and Markings

    5 minutes

    Your injector will take before photos for your medical records and to track your results. They may mark strategic injection points on your lips using a surgical marker. These marks guide precise placement of the filler for symmetry and balance.

  • Step 2: Numbing

    10–15 minutes

    Most clinics apply a topical numbing cream to your lips and the surrounding area. This sits on your skin for 10-15 minutes to take effect. Additionally, most HA fillers in Australia contain lidocaine, a local anaesthetic that further reduces discomfort during injection.

  • Step 3: The Injections

    10–20 minutes

    Using a very fine needle or a blunt-tipped cannula, your injector will strategically place small amounts of filler into different areas of your lips. This might include the body of your upper and lower lips, your cupid’s bow, or the lip border, depending on your treatment plan.

    You’ll feel some pressure and a slight pinch with each injection, but it shouldn’t be painful. Your injector will massage each injection site gently to distribute the product evenly. The entire injection process for lip filler typically takes 15-30 minutes at most.

  • Step 4: Assessment and Cleanup

    Once the filler is placed, you and your injector will assess the immediate results together. Your lips will be swollen right away, so they’ll look larger than your final result. Your injector will clean off the markings and may apply ice to reduce swelling.

Aftercare: How to Look After Your Lips Post-Treatment

Following proper aftercare instructions helps ensure the best possible results and minimises complications. For the first 24-48 hours after your lip filler procedure…

  • Do:

    • Apply ice packs to reduce swelling
    • Take paracetamol if you’re uncomfortable (avoid ibuprofen for 48 hours)
    • Keep your lips hydrated with a gentle balm
    • Sleep with your head elevated
    • Stay hydrated by drinking plenty of water
  • Don’t:

    • Kiss or engage in activities that put pressure on your lips
    • Exercise intensely or do hot yoga (heat increases swelling)
    • Drink alcohol (it thins your blood and increases bruising)
    • Apply makeup to your lips for 24 hours
    • Have dental work, facials, or other facial treatments for at least two weeks
    • Expose your lips to extreme heat (saunas, hot showers, sunbathing) for 48 hours
    • Massage or apply pressure to your lips unless directed by your injector

Choosing the Right Provider in Victoria

This beginner’s guide to lip fillers can’t stress this enough: your choice of injector matters more than the brand of filler used. In Australia, lip fillers are classified as Schedule 4 Prescription Medicines by the Therapeutic Goods Administration (TGA), which means they must be administered by qualified medical professionals – typically doctors, nurses, or dentists with specific training in aesthetic injectables.

Look for providers who:

  • Have medical qualifications and specific training in facial anatomy and injectable treatments
  • Can show you examples of their work (keeping in mind TGA advertising restrictions)
  • Take time during consultations rather than rushing you into treatment
  • Discuss risks honestly, not just benefits
  • Have a protocol for managing complications
  • Use only TGA-approved products from reputable suppliers

Avoid practitioners operating from beauty salons or spas without proper medical oversight, and be wary of deals that seem too cheap; quality fillers and experienced injectors come at a fair price for a reason.

Is Lip Filler Right for You?

Lip fillers work beautifully for many people, but they’re not for everyone. You’re likely a good candidate if you:

  • Are over 18 (most practitioners recommend 21+)
  • Want to enhance your natural lip shape, add volume, or improve symmetry
  • Have realistic expectations about results
  • Are in good general health
  • Don’t have active oral infections, cold sores, or certain medical conditions
  • Understand the temporary nature of the treatment

You should avoid or postpone lip fillers if you’re pregnant or breastfeeding, have a history of severe allergic reactions, or have unrealistic expectations about achieving a specific celebrity’s look. A thorough review of expected risks and potential side effects will be discussed in detail during your personalized consultation, ensuring you are fully informed and comfortable with your treatment plan.

Ready to Take the Next Step?

Getting lip fillers for the first time doesn’t have to be daunting. Armed with this lip filler consultation guide and understanding of how lip fillers work, you’re well-prepared to have an informed conversation with a qualified injector.

At Dr Fresh, our experienced team specialises in natural-looking lip enhancement tailored to your unique facial features. We take the time to understand your aesthetic goals and create a personalised treatment plan that enhances your confidence without compromising your natural beauty. 

Book a consultation with Dr Fresh to discuss your lip filler options and take the first step toward achieving the lips you’ve always wanted.

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Comparing Modern Skin Boosters: Technique, Results & Suitability

Comparing Modern Skin Boosters: Technique, Results & Suitability

Skin-Boosters-Comparision

Ever looked in the mirror and felt like your skin’s lost its bounce? You’re using all the serums, drinking your water, and still – the dullness, the fine lines, the texture just won’t budge. Here’s what most women don’t realise: sometimes the problem isn’t what you’re putting on your skin, but what’s missing beneath it.

Enter skin boosters. These aren’t your standard dermal filler treatments. Instead of adding volume, skin boosters work at a cellular level to restore hydration, stimulate collagen, and genuinely improve your skin’s health from within. But with options like Rejuran Treatment, Bio Remodeling, and Bio Stimulation all claiming different benefits, which one actually suits your skin?

This skin booster comparison breaks down exactly how these three treatments differ, from injection technique to results and who they’re actually best for. 

Key Insights

  • Rejuran uses salmon DNA (polynucleotides) to heal and repair damaged skin. This works best for acne scarring, sensitivity, and skin regeneration.
  • Bio Remodeling contains pure hyaluronic acid that spreads naturally for deep hydration and skin tightening; ideal for fine lines and skin laxity.
  • Bio Stimulation combines amino acids with hyaluronic acid to stimulate collagen and elastin, making it perfect for delicate areas like under-eyes and overall texture improvement.
  • All three require 2-4 sessions initially, with maintenance every 6-12 months.
  • Results appear progressively over 2-4 weeks, with minimal downtime (24-72 hours of mild redness/swelling).

What Actually Makes Skin Boosters Different?

Before we dive into the Rejuran vs Bio Remodeling vs Bio Stimulation debate, let’s clear something up. Skin boosters are fundamentally different from traditional dermal fillers. While fillers add volume to specific areas (think plumper lips or defined cheeks), skin boosters treatment focus entirely on improving your skin’s quality.

Think of it this way: fillers are like adding padding to a worn-out couch, while skin boosters are like restoring the fabric itself. Skin boosters are injected into the upper layers of your skin, where they work to hydrate, stimulate collagen production, and improve overall texture and tone.

The result? Skin that genuinely looks healthier, not just temporarily fuller. You’ll notice improved radiance, better moisture retention, and a reduction in fine lines, all without changing your facial structure.

Dr-Fresh-Cosmetic-Treatments-Skin-Boosters

Skin Booster Comparison: Rejuran vs Bio Remodeling vs Bio Stimulation

Feature Rejuran Bio Remodeling Bio Stimulation
Results timeline 2-4 weeks after your first session, with continued improvement over the following months Within a week, with full effects becoming apparent in 4-8 weeks post-treatment Noticeable but subtle improvement in 2-4 weeks
Sessions required 3-4 initial sessions spaced 2-4 weeks apart, with maintenance treatments every 6-12 months 2 sessions spaced 4 weeks apart, with maintenance treatments every 6-9 months 4 sessions spaced 1-2 weeks apart, with maintenance treatments every 6-9 months. 
Best suited for Acne-scarred skin    Sensitive or compromised skin      Thin or ageing skin Post-procedure recovery Early to moderate skin ageing Needle-averse patients Those wanting an all-over glow Delicate under-eye area Fine lines and crepey skin Those wanting gentle improvement Combination skin concerns
Downtime 2-3 days (small bumps, redness, mild swelling) 24-48 hours (mild redness and small bumps) 1-3 days (mild redness and small bumps)

Rejuran: The Skin Healer

What It Is

Rejuran is often called the “salmon sperm facial” – and yes, that’s actually what it contains. But don’t let that put you off. Rejuran uses polynucleotides (PN) extracted from salmon DNA, which are remarkably similar to human DNA. These polynucleotides act as powerful cellular messengers, telling your skin cells to repair and regenerate.

How It Works

Unlike hyaluronic acid-based boosters that focus primarily on hydration, Rejuran works at a deeper cellular level. The polynucleotides stimulate fibroblast activity (the cells responsible for producing collagen and elastin), reduce inflammation, and actively repair damaged tissue. According to research published in the Journal of Cosmetic Dermatology, polynucleotide treatments have been shown to significantly improve skin elasticity and reduce wrinkle depth.

The treatment involves multiple small injections across the face, which can make it slightly more uncomfortable than other skin boosters. Most practitioners apply a numbing cream beforehand, so discomfort is minimal. You can read more about the science behind rejuran in this guide.

Results

  • Improved skin texture and firmness
  • Reduced appearance of acne scars and enlarged pores
  • Better skin barrier function (less sensitivity and redness)
  • Smoother fine lines and wrinkles
  • More resilient, healthier-looking skin overall
Rejuran Treatment

Bio Remodeling: The Bio-Remodeller

What It Is

Bio Remodeling takes a completely different approach. It uses 100% pure, ultra-concentrated hyaluronic acid, but not the cross-linked kind found in traditional fillers. Instead, Bio Remodeling contains both high and low molecular weight hyaluronic acid that spreads naturally beneath the skin like honey.

How It Works

Here’s what makes Bio Remodeling unique: it’s injected at just five strategic points on each side of your face (these are called Bio Aesthetic Points or BAPs). From these ten injection points, the product spreads evenly across broad zones of skin, thanks to its unique hybrid formulation.

Once beneath the skin, Bio Remodeling triggers the production of four different types of collagen and elastin. This bio-remodelling effect essentially “wakes up” dormant skin cells and encourages them to function like younger skin cells would. 

Results 

  • Deeply hydrated, dewy-looking skin
  • Improved skin firmness and elasticity
  • Lifted appearance, particularly around the jawline and neck
  • Smoothed fine lines and wrinkles
  • Better skin tone and texture
Bio Remodeling Treatment

Bio Stimulation: The Collagen Stimulator

What It Is

Bio Stimulation takes yet another approach, combining hyaluronic acid with a patented blend of six amino acids. This unique formula is specifically designed to target the extracellular matrix (the “scaffolding” that supports your skin cells) and stimulate both collagen and elastin production simultaneously.

How It Works

Bio Stimulation explained: The amino acids in Bio Stimulation (glycine, L-proline, L-leucine, L-lysine, and L-valine) work synergistically with hyaluronic acid to trigger fibroblast activity. What makes this special is the precise ratio of amino acids, which mimics the natural composition of the dermal extracellular matrix.

Bio Stimulation is injected using micro-injections across the treatment area. It’s particularly valued for its versatility, it can be safely used in delicate areas where other treatments might be too aggressive, including directly under the eyes and on the eyelids.

Results 

  • Improved skin elasticity and firmness
  • Reduced appearance of fine lines and crepey texture
  • Better hydration, particularly in thin or delicate skin
  • More even skin tone and improved radiance
  • Smoother under-eye area with reduced hollowing
Bio Stimulate Treatment

Can You Combine Skin Boosters?

Absolutely. Many practitioners recommend combining different skin boosters to target multiple concerns. For example, you might have Rejuran for acne scarring plus Bio Remodeling for overall hydration and tightening. Or Bio Stimulation under the eyes with Bio Remodeling on the rest of the face.

You can also combine skin boosters with other treatments like dermal fillers (for volume), anti-wrinkle injections, or laser treatments. Your practitioner can create a comprehensive treatment plan based on your specific goals.

Ready to Choose Your Skin Booster?

If you’re serious about improving the quality of your skin, the right skin booster can genuinely transform how your skin looks and feels. Whether you’re dealing with acne scarring, fine lines, or just want that coveted “glass skin” glow, there’s a treatment that matches your needs.

At Dr Fresh, we specialise in all three of these advanced skin boosters and can help you determine which is best suited to your skin. Our experienced practitioners will assess your skin, explain your options clearly, and create a personalised treatment plan that delivers real results. 

Our priority is your safety, which is why we screen every client carefully. To ensure the highest level of care, please note that certain treatments are not suitable for all individuals, particularly those who are pregnant, breastfeeding, have active skin infections or inflammation in the treatment area, or have a known allergy. A detailed discussion of these contraindications will take place during your private consultation. 

Book a consultation with Dr Fresh to discover which skin booster is best for you and will give your skin the treatment it deserves.

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What Is Bio Stimulation? The Science Behind This Next-Generation Skin Booster

Bio Stimulate

Ever looked at your reflection and noticed fine lines creeping in around your eyes, or skin that just doesn’t bounce back like it used to? From your late twenties onwards, your skin’s natural collagen and elastin production starts to slow down. Many people concerned about these changes are using Bio Stimulation to boost skin rejuvenation. But what is Bio Stimulation, and is it the right option for your skin concerns?

Bio Stimulation is an injectable treatment that combines hyaluronic acid with a patented blend of six amino acids to stimulate your skin’s own collagen and elastin production. Unlike dermal fillers that add volume or structure, Bio Stimulation treatment works at a cellular level to regenerate your skin’s extracellular matrix; essentially rebuilding your skin’s foundation from within.

Key Insights

  • Bio Stimulation combines low-molecular-weight hyaluronic acid with six specific amino acids (glycine, L-proline, L-leucine, L-lysine, L-valine, and L-alanine).
  • Stimulates natural collagen and elastin synthesis through a process called dermal biogenesis.
  • Targets delicate areas like under-eyes, neck, décolletage, and hands without adding volume.
  • Requires 3-4 sessions spaced 7-10 days apart, with results lasting up to 6 months.
  • Ideal for fine lines, crepey skin, dark circles, and loss of elasticity.

How It Actually Works: Bio Stimulation Explained

Think of your skin’s extracellular matrix (ECM) like the scaffolding that keeps everything firm and structured. It’s made up of collagen, elastin, and hyaluronic acid – three proteins that give skin its bounce, flexibility, and hydration. As we age, this scaffolding starts to break down.

Bio Stimulation works by directly targeting the fibroblasts (the cells responsible for producing collagen and elastin).

A clinical study published in the Journal of Clinical Trials found that the combination of hyaluronic acid and amino acids in Bio Stimulation can stimulate both collagen and elastin production, triggering what’s called “dermal biogenesis” – literally, skin regeneration.

Bio Stimulation works

The patented formula contains six specific amino acids that act as building blocks. Think of it like this: hyaluronic acid brings the hydration and signals your skin cells to work, whilst the amino acids provide the raw materials needed to actually build new collagen and elastin. It’s a two-part system that addresses both hydration and structural support.

What makes Bio Stimulation particularly unique is its ability to protect existing hyaluronic acid by inhibiting Hyaluronidase, the enzyme responsible for breaking down hyaluronic acid in your skin. So you’re not just adding hydration, you’re helping your skin hold onto it longer.

What Can Bio Stimulation Treat?

Bio Stimulation is incredibly versatile. Here’s what this skin booster can genuinely address:

  • skin around eyes

    Around the Eyes

    Those dark circles, under-eye hollows, crow’s feet, and crepey eyelid skin respond particularly well to Bio Stimulation. Because the under-eye area has such delicate, thin skin, traditional fillers can sometimes look unnatural here. Bio Stimulation improves skin quality without adding bulk.

  • Face and Neck Area

    Face and Neck

    Fine lines, wrinkles, loss of elasticity, and that overall dullness that makes you look tired. Bio Stimulation treatment hydrates deeply whilst stimulating your skin to rebuild itself, giving you a fresher, more rested appearance.

  • Skin around hand area

    Décolletage and Hands

    These areas show ageing quickly: sun damage, crepiness, and visible veins or tendons. Bio Stimulation can smooth texture and improve skin thickness in these commonly overlooked zones.

  • Acne-scarring

    Acne Scars and Stretch Marks

    Research published in the National Center for Biotechnology Information showed that the mixture of low-molecular-weight hyaluronic acid and amino acids can improve the appearance of stretch marks when injected using a specific intradermal technique. The regeneration of the extracellular matrix helps to rebuild scarred or damaged tissue.

How Does Bio Stimulation Compare to Other Skin Boosters?

If you’re researching skin treatments, you’ve probably come across bioremodelling treatments. here’s how Bio Stimulation stacks up in a skin booster comparison.

Feature Bio Stimulation Bio Remodelling Polynucleotides
Best For Fine lines, crepey skin, dark circles, delicate areas (eyes, neck), acne scars, early signs of ageing Overall skin laxity, dehydration, loss of firmness, mid-to-lower face and neck sagging Sun damage, reactive skin, inflammation, overall cellular health and skin resilience
Treatment Areas Face, under-eyes, neck, décolletage, hands, even stretch marks Face, neck, décolletage, hands (not typically under-eyes) Face, neck, under-eyes, décolletage
Number of Sessions 3-4 sessions, 7-10 days apart 2 sessions, 4 weeks apart 3-4 sessions, 2-4 weeks apart
Results Last 6 months (up to 8 months in some cases) 6-9 months 6-9 months

Bio Stimulation vs Bio Remodelling: 

Both are excellent, but they work differently. Bio Remodelling contains one of the highest concentrations of hyaluronic acid available and spreads throughout the skin to deliver intense hydration and bio-remodelling. It’s brilliant for improving overall skin laxity and dehydration, particularly on the mid-to-lower face and neck.

Bio Stimulation, on the other hand, combines hyaluronic acid with amino acids to specifically target the extracellular matrix. This makes it gentler and more suitable for delicate areas like the under-eyes, where Bio Remodelling might be too heavy. Bio Stimulation stimulates collagen production more directly through amino acid delivery, whilst Bio Remodelling relies primarily on its high HA concentration to trigger fibroblast activity.

Bio Stimulation vs Polynucleotides

Polynucleotides (often called salmon sperm facials) are made from filtered DNA fragments that work at a cellular level to repair, regenerate, and strengthen your skin barrier. They’re excellent for reactive, sun-damaged, or stressed skin.

Bio Stimulation focuses specifically on collagen and elastin synthesis through amino acid delivery, whilst polynucleotides improve overall cellular function and skin resilience. Many practitioners use them in combination for comprehensive skin rejuvenation treatment— Bio Stimulation for structural rebuilding and polynucleotides for cellular repair.

The Treatment Process: What to Expect

A full Bio Stimulation treatment protocol typically involves four sessions spaced 7-10 days apart. Each session takes around 30 minutes..

Your practitioner will inject Bio Stimulation into the mid-to-deep dermis using very fine needles (32-34 gauge). The technique varies depending on the treatment area — facial treatments often use multiple small injection points in a grid pattern, whilst under-eye treatments require an even more delicate approach.

You’ll likely see some redness, mild swelling, or small bumps at injection sites immediately after treatment. This usually settles within a few hours to a day. Some people experience light bruising, which can be easily covered with makeup and typically fades within a week.

When will you see results?

This isn’t an instant gratification treatment. Because Bio Stimulation works by stimulating your skin’s own regenerative processes, visible improvements develop gradually over several weeks. Most people start noticing changes after the second or third session, with optimal results appearing 4-8 weeks after completing the full protocol.



Bio Stimulation Treatment Process Infographic

How Long Do Results Last?

Results from Bio Stimulation treatment can last up to six months or so. This varies based on your age, lifestyle, skin condition, and how well you care for your skin afterwards.

Factors that affect longevity include smoking (which breaks down hyaluronic acid faster), sun exposure, stress levels, and your overall skincare routine. People who exercise intensely or do a lot of cardio may also metabolise the hyaluronic acid more quickly.

Most practitioners recommend maintenance treatments every 6 months to keep results looking their best. Some people opt for a more intensive maintenance schedule with single sessions every 3-4 months if they have severely damaged skin or want to stay ahead of ageing.

Is Bio Stimulation Right for You?

Bio Stimulation treatment is ideal if you’re noticing:

  • Fine lines and wrinkles, especially around delicate areas
  • Thin, crepey skin that’s lost its plumpness
  • Dark circles or hollowing under the eyes
  • Dehydrated, dull skin lacking radiance
  • Loss of elasticity or early sagging
  • Sun damage or uneven texture

It’s particularly suited for people who want to improve skin quality without the “done” look that sometimes comes with fillers. You’ll still look like yourself, but fresher, more rested, and with healthier skin.

Who should avoid Bio Stimulation? 

Like any injectable treatment, it’s not suitable if you’re pregnant or breastfeeding, have active skin infections or inflammation in the treatment area, or have a known allergy to hyaluronic acid or any of the amino acids in the formula.

Discover Your Perfect Treatment: Safety, Suitability, and Success

While we are passionate about delivering exceptional results and boosting your confidence, our priority is your safety, which is why we screen every client carefully. To ensure the highest level of care, please note that certain treatments are not suitable for all individuals, particularly those who are pregnant, breastfeeding, have active skin infections or inflammation in the treatment area, or have a known allergy to hyaluronic acid or any of the amino acids in the formula. A detailed discussion of these risks and side effects will take place during your private consultation. 

Discover Natural Rejuvenation from Within

For those exploring non-surgical options for skin rejuvenation, Bio Stimulation offers a middle ground between basic skincare and more invasive procedures. It’s not an instant fix, but for people who want natural-looking, gradual improvements in skin quality, it’s one of the most effective options available.

Ready to explore whether Bio Stimulation treatment is right for your skin concerns? Book a consultation with a qualified practitioner at Dr Fresh. We will assess your skin, create a tailored treatment plan, and help you understand exactly what Bio Stimulation can do for you.

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What is Dermal Filler Treatment?

If you are considering dermal filler treatment, you may have come across a wide range of information online – some of it helpful, some of it confusing. This overview is intended to provide clear, balanced information about what dermal fillers are, what the treatment process involves, and what risks and considerations are important to keep in mind.

What Is Dermal Filler? 

Dermal fillers are gel-like substances that are injected under the skin. Depending on the area treated, they may be used to add or restore volume, provide structural support, or soften the appearance of certain lines.

Most commonly, modern dermal fillers are made from a synthetic form of hyaluronic acid. Hyaluronic acid is a type of sugar molecule that naturally occurs in the body and helps retain moisture. Results from treatment vary between individuals, depending on factors such as the area treated, the type of product used, and individual healing responses.

What to Expect at a Dermal Filler Appointment

Treatment begins with a consultation. This is an opportunity to discuss your medical history, treatment goals, and any questions or concerns you may have. A qualified health professional will assess your facial anatomy and determine whether dermal filler treatment is appropriate for you.

If treatment proceeds, the procedure usually involves injections into specific areas. Many filler products include a local anaesthetic to reduce discomfort, and a topical numbing cream may also be used. Some people experience the treatment as mildly uncomfortable, while others may find certain areas more sensitive.

Possible Side Effects and Risks

As with any medical procedure, dermal fillers carry potential risks. These can include:

  • Redness, swelling, or bruising at the injection site
  • Tenderness or pain
  • Lumps or unevenness
  • Allergic reaction
  • Infection
  • Delayed healing
  • Rare but serious complications such as accidental injection into a blood vessel, which may require urgent medical treatment

The degree and duration of side effects can vary between individuals. Your practitioner will discuss these risks in detail during your consultation and explain how complications would be managed if they occur.

Common Misconceptions About Dermal Fillers

“They will make me look unnatural.”

Outcomes vary and depend on factors such as technique, dosage, and individual anatomy. Some people notice subtle changes, while others may experience more noticeable effects.

“There is a long recovery period.”

Recovery experiences differ. Some people resume normal activities soon after treatment, while others may have swelling, bruising, or tenderness for several days.

“Once I start, I can’t stop.”

Hyaluronic acid-based dermal fillers are temporary and are gradually broken down by the body. Depending on the area and product used, results may last between several months and over a year. In some cases, a treatment called hyaluronidase can be used to dissolve filler if required.

Who Can Perform Dermal Filler Treatments?

In Australia, dermal fillers may only be prescribed by a doctor, and administration can be performed by suitably qualified health professionals such as doctors, nurse practitioners, or registered nurses working under a prescription. Dentists may also administer fillers in specific circumstances related to oral health.

It is important to ensure that your injector is appropriately qualified and registered with the Australian Health Practitioner Regulation Agency (AHPRA).

How Dermal Filler Compares to Other Treatments

It’s easy to mix up fillers with other injectables, especially anti-wrinkle treatments.

The main difference?

  • Dermal fillers add volume
  • Anti-wrinkle injections (like Botox) relax muscles to reduce movement and soften lines

They can work together depending on your goals, but they’re not interchangeable. Your practitioner can help you decide what’s best for your face and your budget.

So, Is Dermal Filler For You?

That’s up to you. If you’re looking to refresh your appearance, enhance certain features, or smooth things out without surgery, dermal filler is a safe, customisable option when done by the right hands. Lip enhancement is one of the most popular starting points for first-time patients and if you’re curious about that specifically, our guide to getting lip filler for the first time covers what to expect in detail.

Just make sure you ask questions, do your research, and choose a qualified injector you trust.

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