Polynucleotides aren’t new to medicine. PDRN has been investigated for tissue regeneration, wound healing, and aesthetic rejuvenation for years, particularly in South Korea, where skincare innovation leads the global market.

When injected into your skin, these DNA fragments get to work in three key ways:

1. Activating Your Skin’s Repair System 

PDRN works via adenosine A₂A receptor activation, angiogenesis, fibroblast proliferation and extracellular matrix remodelling. Translation? It activates your skin’s natural healing mechanisms and prompts dormant fibroblast cells to produce collagen and elastin again.

2. Boosting Collagen Production

The polynucleotides in Rejuran provide the building blocks that boost collagen and elastin production in the skin. Your skin becomes firmer, more elastic, and better able to hold moisture.

3. Reducing Inflammation 

PN has wound healing and anti-inflammatory properties, which makes it particularly effective for treating acne scarring, rosacea, and skin that’s damaged from sun exposure or ageing. The beauty of this approach is that you’re not temporarily masking problems, you’re supporting your skin’s ability to regenerate itself.

The results from a salmon sperm facial aren’t instant like Botox or filler. This is a regenerative treatment, so you’re waiting for your skin cells to regenerate.

• Week 1-2: You might notice your skin looks slightly more hydrated and glowy as the swelling subsides.
• Week 2-4: You can often start to notice tangible results, like improved skin texture, smaller pores, and reduced dullness. 
• Week 4-6: Collagen production really kicks in – fine lines soften, scarring improves, and your skin has that plump, healthy appearance.

Typically, the results of a salmon sperm facial last for around six months, but some patients report effects lasting up to a year.

For optimal results, a course of three treatments is recommended, with sessions spaced 2-4 weeks apart. After the initial treatment, a maintenance session every 6-12 months will help preserve skin health and rejuvenation.

The good news? With over 10 million syringes sold globally, no significant adverse events have been reported.

Common Side Effects (usually resolve within 1-2 days):

• Temporary redness, swelling, bruising or mild irritation
• Raised bumps at injection sites
• Minor bleeding or pinprick marks
• Temporary tightness or tenderness

Who Should Be Cautious 

Be cautious if you have fish allergies or chronic inflammatory skin conditions such as rosacea or eczema. While the DNA is highly purified and fish allergies shouldn’t be an issue, it’s worth discussing with your practitioner if you have concerns.

Pregnant or breastfeeding women should avoid the treatment due to limited safety data.

Important Regulatory Note 

Injectable PDRN is TGA-approved in Australia. This means clinics here can legally offer Rejuran treatments with proper medical oversight. Given the current state of research and the potential risks, it’s advisable to only receive treatment from qualified medical professionals using genuine, TGA-approved products.

Rejuran isn’t a budget-friendly treatment. Here’s what you can expect to pay in Australia:

In Australia, the average cost is $700-$900 per session, but this varies depending on:

• The treatment area (full face vs under-eyes only)
• How many vials you need
• Your practitioner’s experience level
• Your location (city clinics typically charge more)

For a full course of three treatments, you’re looking at $2,000-$3,000. Add annual maintenance, and it’s a significant investment.

This treatment isn’t for everyone, but it might be right for you if you’re dealing with:

• Fine lines and loss of elasticity
• Acne scarring or uneven texture
• Dull, dehydrated skin that won’t respond to topicals
• Dark circles or hollowing under the eyes
• Sun damage or photoageing
• Rosacea or chronic inflammation

It’s particularly appealing if you want skin improvements without the frozen look of Botox or the volume of filler. You’re essentially giving your skin the tools to repair itself. Your suitability, risks and side effects can be discussed further in your consultation. You also can check our our comparison guide for different modern skin boosters to see which one is suitable for you.

The salmon sperm facial might sound like marketing madness, but the science behind Rejuran is solid. It’s not a miracle cure that’ll reverse 20 years of sun damage overnight, but it is a genuinely innovative approach to skin rejuvenation that works with your body’s natural healing processes.

At Dr Fresh, our experienced cosmetic stay at the forefront of advanced Rejuran salmon sperm facial in melbourne that deliver real, lasting results. While Rejuran is making waves in the aesthetics industry, we offer a comprehensive range of treatments tailored to your unique skin concerns – from skin boosters and bio-remodellers to targeted solutions for acne scarring, pigmentation, and anti-ageing.

Book a consultation with our team to discuss whether regenerative treatments like polynucleotides are right for your skin goals.